Integrating proteomic data with metabolic modeling provides insight into key pathways of Bordetella pertussis biofilms.

ABSTRACT: Pertussis, commonly known as whooping cough is a severe respiratory disease caused by the bacterium, Bordetella pertussis. Despite widespread vaccination, pertussis resurgence has been observed globally. The development of the current acellular vaccine (ACV) has been based on planktonic studies. However, recent studies have shown that B. pertussis readily forms biofilms. A better understanding of B. pertussis biofilms is important for developing novel vaccines that can target all aspects of B. pertussis infection. This study compared the proteomic expression of biofilm and planktonic B. pertussis cells to identify key changes between the conditions. Major differences were identified in virulence factors including an upregulation of toxins (adenylate cycla

SUBMITTER: Suyama H 

PROVIDER: S-EPMC10435875 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature