High SNRPA1 expression leads to poor prognosis in patients with lung adenocarcinoma.

ABSTRACT:

Objective

SNRPA1, a subunit of spliceosome complex, has been implicated in diverse cancers, while its biological effect in LUAD remains elusive. Therefore, we sought to decipher the relationship between SNRPA1 expression and the prognosis of patients with LUAD and reveal the underlying molecular mechanism.

Materials and methods

Based on the clinical data from TCGA databases, the multivariate Cox model was constructed to screen the prognostic value of SNRPA1. qRT-PCR and immunohistochemical staining were used to examine SNRPA1 mRNA and protein expression in LUAD. The effect of SNRPA1 on LUAD cell proliferation, migration, and epithelial mesenchymal transformation were examined using colony formation assays, wound healing, and western blot assays, respectively. Finally, the in

SUBMITTER: Yang JJ 

PROVIDER: S-EPMC10435942 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature