Quantitative imaging biomarkers of coronary plaque morphology: insights from EVAPORATE.

ABSTRACT:

Aims

Residual cardiovascular risk persists despite statin therapy. In REDUCE-IT, icosapent ethyl (IPE) reduced total events, but the mechanisms of benefit are not fully understood. EVAPORATE evaluated the effects of IPE on plaque characteristics by coronary computed tomography angiography (CCTA). Given the conclusion that the IPE-treated patients demonstrate that plaque burden decreases has already been published in the primary study analysis, we aimed to demonstrate whether the use of an analytic technique defined and validated in histological terms could extend the primary study in terms of whether such changes could be reliably seen in less time on drug, at the individual (rather than only at the cohort) level, or both, as neither of these were established by the primary study r

SUBMITTER: Buckler AJ 

PROVIDER: S-EPMC10435977 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature