Assessing the evolution of SARS-CoV-2 lineages and the dynamic associations between nucleotide variations.

ABSTRACT: Despite seminal advances towards understanding the infection mechanism of SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2), it continues to cause significant morbidity and mortality worldwide. Though mass immunization programmes have been implemented in several countries, the viral transmission cycle has shown a continuous progression in the form of multiple waves. A constant change in the frequencies of dominant viral lineages, arising from the accumulation of nucleotide variations (NVs) through favourable selection, is understandably expected to be a major determinant of disease severity and possible vaccine escape. Indeed, worldwide efforts have been initiated to identify specific virus lineage(s) and/or NVs that may cause a severe clinical presentation or facilitate vaccina

SUBMITTER: Gupta A 

PROVIDER: S-EPMC10436015 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature