Pancreatic steatosis and iron overload increases cardiovascular risk in non-alcoholic fatty liver disease.

ABSTRACT:

Objective

To assess the prevalence of pancreatic steatosis and iron overload in non-alcoholic fatty liver disease (NAFLD) and their correlation with liver histology severity and the risk of cardiometabolic diseases.

Method

A prospective, multicenter study including NAFLD patients with biopsy and paired Magnetic Resonance Imaging (MRI) was performed. Liver biopsies were evaluated according to NASH Clinical Research Network, hepatic iron storages were scored, and digital pathology quantified the tissue proportionate areas of fat and iron. MRI-biomarkers of fat fraction (PDFF) and iron accumulation (R2*) were obtained from the liver and pancreas. Different metabolic traits were evaluated, cardiovascular disease (CVD) risk was estimated with the atherosclerotic CVD score, and th

SUBMITTER: Marti-Aguado D 

PROVIDER: S-EPMC10436077 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature