A multimodal meta-analysis of gray matter alterations in trigeminal neuralgia

ABSTRACT:

Background

Brain gray matter alterations in patients with trigeminal neuralgia (TN) have been detected in prior neuroimaging studies, but the results are heterogeneous. The current study conducted coordinate-based meta-analyses across neuroimaging studies, aiming to find the pattern of brain anatomic and functional alterations in patients with TN.

Methods

We performed a systematic literature search of PubMed, Embase, and Web of Science to identify relevant publications. A multimodal meta-analysis for whole-brain voxel-based morphometry (VBM) studies and functional imaging studies in TN was performed using anisotropic effect size-based signed differential mapping.

Results

The meta-analysis comprised 10 VBM studies with 398 TN patients and 275 healthy controls, and

SUBMITTER: Huang X 

PROVIDER: S-EPMC10436096 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature