Adjusting FRAX Estimates of Fracture Probability Based on a Positive Vertebral Fracture Assessment.

ABSTRACT:

Importance

FRAX is the most widely used and validated fracture risk prediction tool worldwide. Vertebral fractures, which are an indicator of subsequent osteoporotic fractures, can be identified using dual-energy x-ray absorptiometry (DXA) vertebral fracture assessment (VFA).

Objective

To assess the calibration of FRAX and develop a simple method for improving FRAX-predicted fracture probability in the presence of VFA-identified fracture.

Design, setting, and participants

This prognostic study analyzed the DXA and VFA results of all individuals who underwent a VFA between March 31, 2010, and March 31, 2018, who were included in the Manitoba Bone Mineral Density Registry. These individuals were randomly assigned to either the development cohort or validation cohort. A

SUBMITTER: Ye C 

PROVIDER: S-EPMC10436131 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature