Diagnostic Performance of the Fibrosis-4 Index and Nonalcoholic Fatty Liver Disease Fibrosis Score in Lean Adults With Nonalcoholic Fatty Liver Disease.

ABSTRACT:

Importance

The diagnostic performance of the fibrosis-4 index (FIB-4) and nonalcoholic fatty liver disease (NAFLD) fibrosis score (NFS) for advanced fibrosis in lean patients with NAFLD is limited.

Objective

To evaluate the diagnostic performance of the FIB-4 and NFS in lean individuals with NAFLD.

Design, setting, and participants

This diagnostic study included adults with biopsy-proven NAFLD from 6 referral centers in Asia from 1995 to 2019. Cohorts were matched by age and sex between the lean and nonlean groups. All statistical analyses were executed from October 2022 to March 2023.

Main outcomes and measures

The diagnostic performance of the FIB-4 and NFS at the current cutoff for advanced hepatic fibrosis in lean (body mass index [BMI] below 23 [calculated

SUBMITTER: Park H 

PROVIDER: S-EPMC10436134 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature