Deep Ocular Phenotyping Across Primary Open-Angle Glaucoma Genetic Burden.

ABSTRACT:

Importance

Better understanding of primary open-angle glaucoma (POAG) genetics could enable timely screening and promote individualized disease risk prognostication.

Objective

To evaluate phenotypic features across genetic burden for POAG.

Design, setting, and participants

This was a cross-sectional, population-based study conducted from 2006 to 2010. Included participants were individuals from the UK Biobank aged 40 to 69 years. Individuals with non-POAG forms of glaucoma were excluded from the analysis. Data were statistically analyzed from October 2022 to January 2023.

Main outcomes and measures

POAG prevalence based on structural coding, self-reports, and glaucoma-related traits.

Results

Among 407 667 participants (mean [SD] age, 56.3 [8.1] years; 21

SUBMITTER: Sekimitsu S 

PROVIDER: S-EPMC10436188 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature