Neuropilin 2 in osteoblasts regulates trabecular bone mass in male mice.

ABSTRACT:

Introduction

Neuropilin 2 (NRP2) mediates the effects of class 3 semaphorins and vascular endothelial growth factor and is implicated in axonal guidance and angiogenesis. Moreover, NRP2 expression is suggested to be involved in the regulation of bone homeostasis. Indeed, osteoblasts and osteoclasts express NRP2 and male and female global Nrp2 knockout mice have a reduced bone mass accompanied by reduced osteoblast and increased osteoclast counts.

Methods

We first examined the in vitro effect of the calciotropic hormone 1,25-dihydroxyvitamin D₃ [1,25(OH)₂D₃] on Nrp2 transcription in osteoblasts. We next generated mice with a conditional deletion of Nrp2 in the osteoblast cell lineage under control of the paired rela

SUBMITTER: Verlinden L 

PROVIDER: S-EPMC10436209 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature