Pubertal timing and functional neurodevelopmental alterations independently mediate the effect of family conflict on adolescent psychopathology.

ABSTRACT: This study tested the hypothesis that early life adversity (ELA) heightens psychopathology risk by concurrently altering pubertal and neurodevelopmental timing, and associated gene transcription signatures. Analyses focused on threat- (family conflict/neighbourhood crime) and deprivation-related ELAs (parental inattentiveness/unmet material needs), using longitudinal data from 1514 biologically unrelated youths in the Adolescent Brain and Cognitive Development (ABCD) study. Typical developmental changes in white matter microstructure corresponded to widespread BOLD signal variability (BOLD_sv) increases (linked to cell communication and biosynthesis genes) and region-specific task-related BOLD_sv increases/decreases (linked to signal transduction, immune and external en

SUBMITTER: Petrican R 

PROVIDER: S-EPMC10436252 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature