Dysregulations of metabolites and gut microbes and their associations in rats with noise induced hearing loss.

ABSTRACT:

Background

Noise exposure could lead to hearing loss and disorders of various organs. Recent studies have reported the close relations of environmental noise exposure to the metabolomics dysregulations and gut microbiota disturbance in the exposers. However, the associations between gut microbial homeostasis and the body metabolism during noise-induced hearing loss (NIHL) were unclear. To get a full understanding of their synergy in noise-associated diseases, it is essential to uncover their impacts and associations under exposure conditions.

Methods

With ten male rats with background noise exposure (≤ 40 dB) as controls (Ctr group), 20 age- and weight-matched male rats were exposed to 95 dB Sound pressure level (SPL) (LN group, n = 10) or 105 dB SPL noise (HN group,

SUBMITTER: Li N 

PROVIDER: S-EPMC10436299 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature