Identification of disulfidptosis-related genes and subgroups in Alzheimer's disease.

ABSTRACT:

Background

Alzheimer's disease (AD), a common neurological disorder, has no effective treatment due to its complex pathogenesis. Disulfidptosis, a newly discovered type of cell death, seems to be closely related to the occurrence of various diseases. In this study, through bioinformatics analysis, the expression and function of disulfidptosis-related genes (DRGs) in Alzheimer's disease were explored.

Methods

Differential analysis was performed on the gene expression matrix of AD, and the intersection of differentially expressed genes and disulfidptosis-related genes in AD was obtained. Hub genes were further screened using multiple machine learning methods, and a predictive model was constructed. Finally, 97 AD samples were divided into two subgroups based on hub genes.

R

SUBMITTER: Ma S 

PROVIDER: S-EPMC10436325 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature