A systematic review of genome-wide association studies for pain, nociception, neuropathy, and pain treatment responses.

ABSTRACT:

Abstract

Pain is the leading cause of disability worldwide, imposing an enormous burden on personal health and society. Pain is a multifactorial and multidimensional problem. Currently, there is (some) evidence that genetic factors could partially explain individual susceptibility to pain and interpersonal differences in pain treatment response. To better understand the underlying genetic mechanisms of pain, we systematically reviewed and summarized genome-wide association studies (GWASes) investigating the associations between genetic variants and pain/pain-related phenotypes in humans. We reviewed 57 full-text articles and identified 30 loci reported in more than 1 study. To check whether genes described in this review are associated with (other) pain phenotypes, we searched 2 pa

SUBMITTER: Li S 

PROVIDER: S-EPMC10436363 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature