Assembly of Rolled-Up Collagen Constructs on Porous Alumina Textiles.

ABSTRACT: Developing new techniques to prepare free-standing tubular scaffolds has always been a challenge in the field of regenerative medicine. Here, we report a new and simple way to prepare free-standing collagen constructs with rolled-up architecture by self-assembling nanofibers on porous alumina (Al₂O₃) textiles modified with different silanes, carbon or gold. Following self-assembly and cross-linking with glutaraldehyde, collagen nanofibers spontaneously rolled up on the modified Al₂O₃ textiles and detached. The resulting collagen constructs had an inner diameter of approximately 2 to 4 mm in a rolled-up state and could be easily detached from the underlying textiles. Mechanical testing of wet collagen scaffolds following detachment yielded mean va

SUBMITTER: Dutta D 

PROVIDER: S-EPMC10436369 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature