Organic Matrix Derived from Host-Microbe Interplay Contributes to Pathological Renal Biomineralization.

ABSTRACT: Matrix stones are a rare form of kidney stones. They feature a high percentage of hydrogel-like organic matter, and their formation is closely associated with urinary tract infections. Herein, comprehensive materials and biochemical approaches were taken to map the organic-inorganic interface and gather insights into the host-microbe interplay in pathological renal biomineralization. Surgically extracted soft and slimy matrix stones were examined using micro-X-ray computed tomography and various microspectroscopy techniques. Higher-mineral-density laminae were positive for calcium-bound Alizarin red. Lower-mineral-density laminae revealed periodic acid-Schiff-positive organic filamentous networks of varied thickness. These organic filamentous networks, which featured a high polysaccharide

SUBMITTER: Bai Y 

PROVIDER: S-EPMC10436370 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature