Tumor microenvironment characterization in colorectal cancer to identify prognostic and immunotherapy genes signature.

ABSTRACT:

Background

The tumor microenvironment (TME) plays a crucial role in tumorigenesis, progression, and therapeutic response in many cancers. This study aimed to comprehensively investigate the role of TME in colorectal cancer (CRC) by generating a TMEscore based on gene expression.

Methods

The TME patterns of CRC datasets were investigated, and the TMEscores were calculated. An unsupervised clustering method was used to divide samples into clusters. The associations between TMEscores and clinical features, prognosis, immune score, gene mutations, and immune checkpoint inhibitors were analyzed. A TME signature was constructed using the TMEscore-related genes. The results were validated using external and clinical cohorts.

Results

The TME pattern landscape was for CRC was

SUBMITTER: Guo XW 

PROVIDER: S-EPMC10436413 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature