Mapping global zoonotic niche and interregional transmission risk of monkeypox: a retrospective observational study.

ABSTRACT:

Background

Outbreaks of monkeypox have been ongoing in non-endemic countries since May 2022. A thorough assessment of its global zoonotic niche and potential transmission risk is lacking.

Methods

We established an integrated database on global monkeypox virus (MPXV) occurrence during 1958 - 2022. Phylogenetic analysis was performed to examine the evolution of MPXV and effective reproductive number (R_t) was estimated over time to examine the dynamic of MPXV transmissibility. The potential ecological drivers of zoonotic transmission and inter-regional transmission risks of MPXV were examined.

Results

As of 24 July 2022, a total of 49 432 human patients with MPXV infections have been reported in 78 countries. Based on 525 whole genome sequences, two main clade

SUBMITTER: Sun YQ 

PROVIDER: S-EPMC10436417 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature