Case Report: A case of complete response to entrectinib in NTRK fusion gene-positive parotid gland cancer.

ABSTRACT:

Introduction

Expression of the NTRK gene is rare in solid tumors but is highly prevalent in salivary gland secretory carcinomas. Here, we report a case of a complete response to entrectinib in a patient with NTRK fusion gene-positive parotid carcinoma.

Case description

The patient was a 44-year-old man who underwent total left parotidectomy and left cervical lymph node dissection for a left parotid tumor at 24 years of age. The histopathological diagnosis was mammary analog secretory carcinoma. Postoperatively, the patient received only radiation therapy. Sixteen years after the surgery, the patient became aware of a mass in the left parotid region. A close examination revealed local recurrence and multiple cervical lymph node metastases. S-1 monotherapy was st

SUBMITTER: Moriyama E 

PROVIDER: S-EPMC10436465 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature