SNPs in cytochrome P450 genes decide on the fate of individuals with genetic predisposition to Parkinson's disease.

ABSTRACT: Parkinson's disease (PD) is one of the most frequent neurological diseases affecting millions of people worldwide. While the majority of PD cases are of unknown origin (idiopathic), about 5%-10% are familial and linked to mutations in different known genes. However, there are also people with a genetic predisposition to PD who do not develop the disease. To elucidate factors leading to the manifestation of PD we compared the occurrence of single nucleotide polymorphisms (SNPs) in various cytochrome P450 (P450) genes in people with a genetic predisposition and suffering from PD (GPD) to that of people, who are genetically predisposed, but show no symptoms of the disease (GUN). We used the PPMI (Parkinson's Progression Markers Initiative) database and the gene sequences of all 57 P450s as we

SUBMITTER: Petkova-Kirova P 

PROVIDER: S-EPMC10436510 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature