Associations of air pollution with all-cause dementia, Alzheimer's disease, and vascular dementia: a prospective cohort study based on 437,932 participants from the UK biobank.

ABSTRACT:

Objective

To prospectively assess whether air pollution, including PM_2.5, PM₁₀, and NOx, is associated with the risk of all-cause dementia, Alzheimer's disease (AD), and vascular dementia, and to investigate the potential relationship between air pollution and genetic susceptibility in the development of AD.

Methods and results

Our study included 437,932 participants from the UK Biobank with a median follow-up period of over 10 years. Using a Cox proportional hazards model, we found that participants exposed to PM_2.5 levels of ≥10 μg/m³ had a higher risk of developing all-cause dementia (HR = 1.1; 95% CI: 1.05-1.28; p < 0.05) compared to the group exposed to PM_2.5 levels of <10 μg/m³. However, there was

SUBMITTER: Yuan S 

PROVIDER: S-EPMC10436530 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature