Genetically predicted circulating levels of cytokines and the risk of depression: a bidirectional Mendelian-randomization study.

ABSTRACT: Objective: Inflammatory cytokines disturbance is the main result of immune dysregulation, which is widely described in major depressive disorder (MDD). However, the potential causal relationship between these two factors has not been discovered. Therefore, the purpose of this study was to investigate the causal relationship between inflammatory cytokines and MDD risk by using the two-sample Mendelian randomization (MR) analysis. Method: Two genetic instruments obtained from publicly available gene profile data were utilized for the analysis. We obtained the genetic variation data of 41 inflammatory cytokines from genome-wide association studies (GWAS) meta-analysis of 8293 individuals of Finnish descent. The MDD data, including 135,458 MDD cases and 344,901 controls, were obt

SUBMITTER: Wang M 

PROVIDER: S-EPMC10436531 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature