Lesion-based indicators predict long-term outcomes of pheochromocytoma and paraganglioma- SIZEPASS.

ABSTRACT:

Aim

We seek a simple and reliable tool to predict malignant behavior of pheochromocytoma and paraganglioma (PPGL).

Methods

This single-center prospective cohort study assessed size of primary PPGLs on preoperative cross-sectional imaging and prospectively scored specimens using the Pheochromocytoma of the Adrenal Gland Scaled Score (PASS). Multiplication of PASS points with maximum lesion diameter (in mm) yielded the SIZEPASS criterion. Local recurrence, metastasis or death from disease were surrogates defining malignancy.

Results

76 consecutive PPGL patients, whereof 58 with pheochromocytoma and 51 female, were diagnosed at a mean age of 52.0 ± 15.2 years. 11 lesions (14.5%) exhibited malignant features at a median follow-up (FU) of 49 months (range 4-172 mo). Median

SUBMITTER: Hanschell H 

PROVIDER: S-EPMC10436571 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature