Streptococcus pneumoniae disrupts the structure of the golgi apparatus and subsequent epithelial cytokine response in an H₂O₂-dependent manner.

ABSTRACT:

Background

Lung infections caused by Streptococcus pneumonia are a global leading cause of death. The reactive oxygen species H₂O₂ is one of the virulence factors of Streptococcus pneumoniae. The Golgi apparatus is essential for the inflammatory response of a eukaryotic cell. Golgi fragmentation was previously shown to be induced by bacterial pathogens and in response to H₂O₂ treatment. This led us to investigate whether the Golgi apparatus is actively involved and targeted in host-pathogen interactions during pneumococcal infections.

Methods

Following in vitro infection of BEAS-2B bronchial epithelial cells with Streptococcus pneumoniae for 16 h, the structure of the Golgi apparatus was assessed by fluorescence staining of the Gol

SUBMITTER: Klabunde B 

PROVIDER: S-EPMC10436572 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature