Dexmedetomidine improves the outcomes for pediatric severe sepsis with mechanical ventilation.

ABSTRACT:

Background

The sedative dexmedetomidine has been shown to reduce mortality in adult patients with severe sepsis, but it is not known whether children benefit. This study explored the effects of dexmedetomidine on the outcomes of children with severe sepsis with mechanical ventilation.

Methods

In this retrospective cohort study, children with severe sepsis requiring mechanical ventilation from 2016 to 2020 were categorized as dexmedetomidine and non-dexmedetomidine group. The propensity score matching was performed to match cases in both groups. The primary outcome was 28-day mortality, and the secondary outcomes were acute kidney injury, ventilator-free days, lengths of PICU and hospital stays. The Kaplan-Meier method and was the log-rank test used to estimate the 28-day mor

SUBMITTER: Zhao C 

PROVIDER: S-EPMC10436587 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature