Intranasal analgesia for acute moderate to severe pain in children - a systematic review and meta-analysis.

ABSTRACT:

Background

Children in acute pain often receive inadequate pain relief, partly from difficulties administering injectable analgesics. A rapid-acting, intranasal (IN) analgesic may be an alternative to other parenteral routes of administration. Our review compares the efficacy, safety, and acceptability of intranasal analgesia to intravenous (IV) and intramuscular (IM) administration; and to compare different intranasal agents.

Methods

We searched Cochrane Library, MEDLINE/PubMed, Embase, Web of Knowledge, Clinicaltrials.gov, Controlled-trials.com/mrcr, Clinicaltrialsregister.eu, Apps.who.int/trialsearch. We also screened reference lists of included trials and relevant systematic reviews. Studies in English from any year were included. Two authors independently assessed all s

SUBMITTER: Prescott MG 

PROVIDER: S-EPMC10436645 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature