Asprosin contributes to nonalcoholic fatty liver disease through regulating lipid accumulation and inflammatory response via AMPK signaling

ABSTRACT: Abstract

Background

Nonalcoholic fatty liver disease (NAFLD) is a primary contributor to liver‐related morbidity and mortality. Asprosin has been reported to be implicated in NAFLD.

Aims

This work is to illuminate the effects of Asprosin on NAFLD and the possible downstream mechanism.

Materials & Methods

The weight of NAFLD mice induced by a high‐fat diet was detected. Quantitative reverse‐transcription polymerase chain reaction (RT‐qPCR) examined serum Asprosin expression. RT‐qPCR and western blot analysis examined Asprosin expression in mice liver tissues. Intraperitoneal glucose tolerance test (IPGTT) and intraperitoneal insulin tolerance test (IPITT) were implemented. Biochemical kits tested liver enzyme levels in mice serum and liver tissues. Hematoxylin and

SUBMITTER: Zhang B 

PROVIDER: S-EPMC10436697 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature