Evaluation of Cell-Specific Epigenetic Age Acceleration in People With Multiple Sclerosis.

ABSTRACT:

Background and objectives

In multiple sclerosis (MS), accelerated aging of the immune system (immunosenescence) may be associated with disease onset or drive progression. DNA methylation (DNAm) is an epigenetic factor that varies among lymphocyte subtypes, and cell-specific DNAm is associated with MS. DNAm varies across the life span and can be used to accurately estimate biological age acceleration, which has been linked to a range of morbidities. The objective of this study was to test for cell-specific epigenetic age acceleration (EAA) in people with MS.

Methods

This was a case-control study of EAA using existing DNAm data from several independent previously published studies. Data were included if .idat files from Illumina 450K or EPIC arrays were available for both a ca

SUBMITTER: Maltby V 

PROVIDER: S-EPMC10437016 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature