Heavy water induces bundling in entangled actin networks.

ABSTRACT: Heavy water is known to affect many different biological systems, with the most striking effects observed at the cellular level. Many dynamic processes, such as migration or invasion, but also central processes of cell proliferation are measurably inhibited by the presence of deuterium oxide (D₂O). Furthermore, individual cell deformabilities are significantly decreased upon D₂O treatment. In order to understand the origin of these effects, we studied entangled filamentous actin networks, a commonly used model system for the cytoskeleton, which is considered a central functional element for dynamic cellular processes. Using bulk shear rheology to extract rheological signatures of reconstituted actin networks at varying concentrations of D₂O, we found a non-

SUBMITTER: Mollenkopf P 

PROVIDER: S-EPMC10437092 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature