The paradigm of IL-23-independent production of IL-17F and IL-17A and their role in chronic inflammatory diseases.

ABSTRACT: Interleukin-17 family (IL-17s) comprises six structurally related members (IL-17A to IL-17F); sequence homology is highest between IL-17A and IL-17F, displaying certain overlapping functions. In general, IL-17A and IL-17F play important roles in chronic inflammation and autoimmunity, controlling bacterial and fungal infections, and signaling mainly through activation of the nuclear factor-kappa B (NF-κB) pathway. The role of IL-17A and IL-17F has been established in chronic immune-mediated inflammatory diseases (IMIDs), such as psoriasis (PsO), psoriatic arthritis (PsA), axial spondylarthritis (axSpA), hidradenitis suppurativa (HS), inflammatory bowel disease (IBD), multiple sclerosis (MS), and asthma. CD4⁺ helper T cells (Th17) activated by IL-23 are well-studied sources of IL-

SUBMITTER: Navarro-Compan V 

PROVIDER: S-EPMC10437113 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature