Commensal Cutibacterium acnes induce epidermal lipid synthesis important for skin barrier function.

ABSTRACT: Lipid synthesis is necessary for formation of epithelial barriers and homeostasis with external microbes. An analysis of the response of human keratinocytes to several different commensal bacteria on the skin revealed that Cutibacterium acnes induced a large increase in essential lipids including triglycerides, ceramides, cholesterol, and free fatty acids. A similar response occurred in mouse epidermis and in human skin affected with acne. Further analysis showed that this increase in lipids was mediated by short-chain fatty acids produced by Cutibacterium acnes and was dependent on increased expression of several lipid synthesis genes including glycerol-3-phosphate-acyltransferase-3. Inhibition or RNA silencing of peroxisome proliferator-activated receptor-α (PPARα),

SUBMITTER: Almoughrabie S 

PROVIDER: S-EPMC10438445 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature