Emergence of linezolid-resistant Enterococcus faecium in a tertiary hospital in Copenhagen.

ABSTRACT: Linezolid is used as first-line treatment of infections caused by vancomycin-resistant Enterococcus faecium. However, resistance to linezolid is increasingly detected. The aim of the present study was to elucidate the causes and mechanisms for the increase in linezolid-resistant E. faecium at Copenhagen University Hospital - Rigshospitalet. We therefore combined patient information on linezolid treatment with whole-genome sequencing data for vancomycin- or linezolid-resistant E. faecium isolates that had been systematically collected since 2014 (n=458). Whole-genome sequencing was performed for multilocus sequence typing (MLST), identification of linezolid resistance-conferring genes/mutations and determination of phylogenetically closely related strains. The co

SUBMITTER: Misiakou MA 

PROVIDER: S-EPMC10438815 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature