XCR1 expression distinguishes human conventional dendritic cell type 1 with full effector functions from their immediate precursors.

ABSTRACT: Dendritic cells (DCs) are major regulators of innate and adaptive immune responses. DCs can be classified into plasmacytoid DCs and conventional DCs (cDCs) type 1 and 2. Murine and human cDC1 share the mRNA expression of XCR1. Murine studies indicated a specific role of the XCR1-XCL1 axis in the induction of immune responses. Here, we describe that human cDC1 can be distinguished into XCR1^- and XCR1⁺ cDC1 in lymphoid as well as nonlymphoid tissues. Steady-state XCR1⁺ cDC1 display a preactivated phenotype compared to XCR1^- cDC1. Upon stimulation, XCR1⁺ cDC1, but not XCR1^- cDC1, secreted high levels of inflammatory cytokines as well as chemokines. This was associated with enhanced activation of NK cells mediated by XCR1^+<

SUBMITTER: Heger L 

PROVIDER: S-EPMC10438835 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature