L. rhamnosus CNCM I-3690 survival, adaptation, and small bowel microbiome impact in human.

ABSTRACT: Fermented foods and beverages are a significant source of dietary bacteria that enter the gastrointestinal (GI) tract. However, little is known about how these microbes survive and adapt to the small intestinal environment. Colony-forming units (CFU) enumeration and viability qPCR of Lacticaseibacillus rhamnosus CNCM I-3690 in the ileal effluent of 10 ileostomy subjects during 12-h post consumption of a dairy product fermented with this strain demonstrated the high level of survival of this strain during human small intestine passage. Metatranscriptome analyses revealed the in situ transcriptome of L. rhamnosus in the small intestine, which was contrasted with transcriptome data obtained from in vitro cultivation. These comparative analyses revealed substantial

SUBMITTER: Zaccaria E 

PROVIDER: S-EPMC10438856 | biostudies-literature | 2023 Jan-Dec

REPOSITORIES: biostudies-literature