AliGater: a framework for the development of bioinformatic pipelines for large-scale, high-dimensional cytometry data.

ABSTRACT:

Motivation

AliGater is an open-source framework to accelerate the development of bioinformatic pipelines for the analysis of large-scale, high-dimensional flow cytometry data. AliGater provides a Python package for automatic feature extraction workflows, as well as building blocks to construct analysis pipelines.

Results

We illustrate the use of AliGater in a high-resolution flow cytometry-based genome-wide association study on 46 immune cell populations in 14 288 individuals.

Availability and implementation

Source code and documentation at https://github.com/LudvigEk/aligater and https://aligater.readthedocs.io.

SUBMITTER: Ekdahl L 

PROVIDER: S-EPMC10438955 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature