Exploitation of ATP-sensitive potassium ion (K_ATP) channels by HPV promotes cervical cancer cell proliferation by contributing to MAPK/AP-1 signalling.

ABSTRACT: Persistent infection with high-risk human papillomaviruses (HPVs) is the causal factor in multiple human malignancies, including >99% of cervical cancers and a growing proportion of oropharyngeal cancers. Prolonged expression of the viral oncoproteins E6 and E7 is necessary for transformation to occur. Although some of the mechanisms by which these oncoproteins contribute to carcinogenesis are well-characterised, a comprehensive understanding of the signalling pathways manipulated by HPV is lacking. Here, we present the first evidence to our knowledge that the targeting of a host ion channel by HPV can contribute to cervical carcinogenesis. Through the use of pharmacological activators and inhibitors of ATP-sensitive potassium ion (K_ATP) channels, we demonstrate that these chann

SUBMITTER: Scarth JA 

PROVIDER: S-EPMC10439009 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature