Effects of daily artificial gravity training on orthostatic tolerance following 60-day strict head-down tilt bedrest.

ABSTRACT:

Purpose

Orthostatic intolerance commonly occurs following immobilization or space flight. We hypothesized that daily artificial gravity training through short-arm centrifugation could help to maintain orthostatic tolerance following head-down tilt bedrest, which is an established terrestrial model for weightlessness.

Methods

We studied 24 healthy persons (eight women; age 33.3 ± 9.0 years; BMI 24.3 ± 2.1 kg/m²) who participated in the 60-days head-down tilt bedrest (AGBRESA) study. They were assigned to 30 min/day continuous or 6 × 5 min intermittent short-arm centrifugation with 1Gz at the center of mass or a control group. We performed head-up tilt testing with incremental lower-body negative pressure until presyncope before and after bedrest. We recorded an ele

SUBMITTER: Hoenemann JN 

PROVIDER: S-EPMC10439060 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature