Early diagnostic and prognostic biomarkers for gastric cancer: systems-level molecular basis of subsequent alterations in gastric mucosa from chronic atrophic gastritis to gastric cancer.

ABSTRACT:

Purpose

It is important to comprehend how the molecular mechanisms shift when gastric cancer in its early stages (GC). We employed integrative bioinformatics approaches to locate various biological signalling pathways and molecular fingerprints to comprehend the pathophysiology of the GC. To facilitate the discovery of their possible biomarkers, a rapid diagnostic may be made, which leads to an improved diagnosis and improves the patient's prognosis.

Methods

Through protein-protein interaction networks, functional differentially expressed genes (DEGs), and pathway enrichment studies, we examined the gene expression profiles of individuals with chronic atrophic gastritis and GC.

Results

A total of 17 DEGs comprising 8 upregulated and 9 down-regulated genes were identif

SUBMITTER: Selvan TG 

PROVIDER: S-EPMC10439097 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature