Differential gut microbiome in spondyloarthritis patients associated to Blastocystis colonization.

ABSTRACT: The role of Blastocystis in intestinal health is an open controversy, and little is known about the potential effect of this microorganism in autoinflammatory diseases such as spondyloarthritis (SpA). Here, we analyzed the gut microbiome of 36 SpA patients and 13 control individuals and demonstrated that the richness, diversity, and taxonomic composition between these two groups are different. We also showed that colonization by Blastocystis in control individuals increases the richness and diversity of the intestinal microbiome, whereas in SpA patients, it does not seem to have any impact. This may reflect a potential role of Blastocystis in sculpting the gut microbiome architecture in control individuals, whereas in subjects with SpA, the modulation of the microbiome may be governed by d

SUBMITTER: Nieto-Clavijo C 

PROVIDER: S-EPMC10439117 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature