Transcriptomic signatures of feline chronic gingivostomatitis are influenced by upregulated IL6.

ABSTRACT: Feline chronic gingivostomatitis (FCGS) is a relatively common and debilitating disease characterized by bilateral inflammation and ulceration of the caudal oral mucosa, alveolar and buccal mucosa, and varying degrees of periodontal disease. The etiopathogenesis of FCGS remains unresolved. In this study, we performed bulk RNA-seq molecular profiling of affected tissues derived from a cohort of client-owned cats with FCGS compared to tissues from unaffected animals, to identify candidate genes and pathways that can help guide future exploration of novel clinical solutions. We complemented transcriptomic findings with immunohistochemistry and in situ hybridization assays to better understand the biological significance of the results and performed RNA-seq validation of biologically relevant

SUBMITTER: Peralta S 

PROVIDER: S-EPMC10439118 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature