Hedgehog signaling in tissue homeostasis, cancers, and targeted therapies.

ABSTRACT: The past decade has seen significant advances in our understanding of Hedgehog (HH) signaling pathway in various biological events. HH signaling pathway exerts its biological effects through a complex signaling cascade involved with primary cilium. HH signaling pathway has important functions in embryonic development and tissue homeostasis. It plays a central role in the regulation of the proliferation and differentiation of adult stem cells. Importantly, it has become increasingly clear that HH signaling pathway is associated with increased cancer prevalence, malignant progression, poor prognosis and even increased mortality. Understanding the integrative nature of HH signaling pathway has opened up the potential for new therapeutic targets for cancer. A variety of drugs have been develop

SUBMITTER: Jing J 

PROVIDER: S-EPMC10439210 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature