Ontology highlight
ABSTRACT:
SUBMITTER: Goldberger Z
PROVIDER: S-EPMC10439248 | biostudies-literature | 2023 Aug
REPOSITORIES: biostudies-literature
Goldberger Zoe Z Hauert Sylvie S Chang Kevin K Kurtanich Trevin T Alpar Aaron T AT Repond Grégoire G Wang Yue Y Gomes Suzana S Krishnakumar Raga R Siddarth Prabha P Swartz Melody A MA Hubbell Jeffrey A JA Briquez Priscilla S PS
Cell reports. Medicine 20230807 8
Immune checkpoint immunotherapy (ICI) can re-activate immune reactions against neoantigens, leading to remarkable remission in cancer patients. Nevertheless, only a minority of patients are responsive to ICI, and approaches for prediction of responsiveness are needed to improve the success of cancer treatments. While the tumor mutational burden (TMB) correlates positively with responsiveness and survival of patients undergoing ICI, the influence of the subcellular localizations of the neoantigen ...[more]