Platelet factor XIII-A regulates platelet function and promotes clot retraction and stability.

ABSTRACT:

Background

Factor XIII (FXIII) is an important proenzyme in the hemostatic system. The plasma-derived enzyme activated FXIII cross-links fibrin fibers within thrombi to increase their mechanical strength and cross-links fibrin to fibrinolytic inhibitors, specifically α₂-antiplasmin, to increase resistance to fibrinolysis. We have previously shown that cellular FXIII (factor XIII-A [FXIII-A]), which is abundant in the platelet cytoplasm, is externalized onto the activated membrane and cross-links extracellular substrates. The contribution of cellular FXIII-A to platelet activation and platelet function has not been extensively studied.

Objectives

This study aims to identify the role of platelet FXIII-A in platelet function.

Methods

We used normal healthy pla

SUBMITTER: Mitchell JL 

PROVIDER: S-EPMC10439398 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature