Laboratory diagnosis of von Willebrand disease in the age of the new guidelines: considerations based on geography and resources.

ABSTRACT: von Willebrand disease (VWD) is considered the most common bleeding disorder and arises from deficiency and/or defect in the adhesive plasma protein von Willebrand factor (VWF). Diagnosis of VWD requires clinical assessment and is facilitated by laboratory testing. Several guidelines for VWD diagnosis exist, with the latest American Society of Hematology, International Society on Thrombosis and Haemostasis, National Hemophilia Foundation, and World Federation of Hemophilia 2021 guidelines presenting 11 recommendations, some of which have drawn controversy. In the current narrative review, we provide additional context around difficulties in laboratory diagnosis/exclusion/typing of VWD, with a focus on developing countries/resource-poor settings. In particular, there are many variations in

SUBMITTER: Favaloro EJ 

PROVIDER: S-EPMC10439443 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature