Delineating disorder-general and disorder-specific dimensions of psychopathology from functional brain networks in a developmental clinical sample.

ABSTRACT: The interplay between functional brain network maturation and psychopathology during development remains elusive. To establish the structure of psychopathology and its neurobiological mechanisms, mapping of both shared and unique functional connectivity patterns across developmental clinical populations is needed. We investigated shared associations between resting-state functional connectivity and psychopathology in children and adolescents aged 5-21 (n = 1689). Specifically, we used partial least squares (PLS) to identify latent variables (LV) between connectivity and both symptom scores and diagnostic information. We also investigated associations between connectivity and each diagnosis specifically, controlling for other diagnosis categories. PLS identified five significant LVs between

SUBMITTER: Voldsbekk I 

PROVIDER: S-EPMC10439505 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature