Whole lung lavage decreases physiological dead space in patients with pulmonary alveolar proteinosis: two case reports.

ABSTRACT:

Background

Pulmonary alveolar proteinosis (PAP) is a rare disease characterized by progressive accumulation of the alveolar surfactant. Whole lung lavage (WLL) using a high volume of warmed saline remains the standard therapy. However, no established bedside monitoring tool can evaluate the physiological effect of WLL in the perioperative period. Indirect calorimetry, which is generally used to measure resting energy expenditure, can detect carbon dioxide (CO₂) production and mixed-expired partial pressure of CO₂ breath by breath. In this physiological study, we calculated CO₂ elimination per breath (VTCO₂,br) and Enghoff's dead space using indirect calorimetry and measured the extravascular lung water index to reveal the effect of WLL.

SUBMITTER: Fujihara T 

PROVIDER: S-EPMC10439532 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature