Paternal high-fat diet altered SETD2 gene methylation in sperm of F0 and F1 mice

ABSTRACT: Paternal high-fat diet (HFD) can alter the epigenetics of sperm DNA, resulting in the transmission of obesity-related traits to the offspring. Previous studies have mainly focused on the HFD-induced changes in DNA methylation of imprinted genes, overlooking the potential involvement of non-imprinted genes in this process. SETD2, an important epigenetically-regulated gene known for its response to environmental stress, remains poorly understood in the context of high-fat diet-induced epigenetic changes. Here we examined the effect of obesity from a HFD on paternal SETD2 expression and methylation in sperm, and embryos at the blastocyst stage and during subsequent development, to determine the alteration of SETD2 in paternal intergenerational and transgenerational inheritance. The result sho

SUBMITTER: Wei S 

PROVIDER: S-EPMC10439541 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature