RBahadur: efficient simulation of structured high-dimensional genotype data with applications to assortative mating.
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ABSTRACT:
SUBMITTER: Border R
PROVIDER: S-EPMC10439545 | biostudies-literature | 2023 Aug
REPOSITORIES: biostudies-literature
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rBahadur: efficient simulation of structured high-dimensional genotype data with applications to assortative mating.
Border Richard R Malik Osman Asif OA
BMC bioinformatics 20230818 1
Existing methods for generating synthetic genotype data are ill-suited for replicating the effects of assortative mating (AM). We propose rb_dplr, a novel and computationally efficient algorithm for generating high-dimensional binary random variates that effectively recapitulates AM-induced genetic architectures using the Bahadur order-2 approximation of the multivariate Bernoulli distribution. The rBahadur R library is available through the Comprehensive R Archive Network at https://CRAN.R-proj ...[more]
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