Human brain solute transport quantified by glymphatic MRI-informed biophysics during sleep and sleep deprivation.

ABSTRACT: Whether you are reading, running or sleeping, your brain and its fluid environment continuously interacts to distribute nutrients and clear metabolic waste. Yet, the precise mechanisms for solute transport within the human brain have remained hard to quantify using imaging techniques alone. From multi-modal human brain MRI data sets in sleeping and sleep-deprived subjects, we identify and quantify CSF tracer transport parameters using forward and inverse subject-specific computational modelling. Our findings support the notion that extracellular diffusion alone is not sufficient as a brain-wide tracer transport mechanism. Instead, we show that human MRI observations align well with transport by either by an effective diffusion coefficent 3.5[Formula: see text] that of extracellular diffusi

SUBMITTER: Vinje V 

PROVIDER: S-EPMC10439559 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature