Skeletal muscle index is associated with long term outcomes after lobectomy for non-small cell lung cancer

ABSTRACT:

Background

Skeletal muscle indices have been associated with improved peri-operative outcomes after surgical resection of non-small-cell lung cancer (NSCLC). However, it is unclear if these indices can predict long term cancer specific outcomes.

Methods

NSCLC patients undergoing lobectomy at our institute between 2009–2015 were included in this analysis (N = 492). Preoperative CT scans were used to quantify skeletal muscle index (SMI) at L4 using sliceOmatic software. Cox proportional modelling was performed for overall (OS) and recurrence free survival (RFS).

Results

For all patients, median SMI was 45.7 cm2/m2 (IQR, 40–53.8). SMI was negatively associated with age (R = -0.2; p < 0.05) and positively associated with BMI (R = 0.46; P < 0.05). No association with

SUBMITTER: Vedire Y 

PROVIDER: S-EPMC10439565 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature